![]() (8) Synthetic sulfinyl compounds often exhibit a significant biological activity. (5−7)Ĭhiral organosulfur derivatives are found in natural systems such as methionine sulfoxide, S-adenosyl methionine, allicin, or leinamycin 1 ( Figure 2). Three important reviews published in the last five years deal with this emerging application of chiral sulfoxides and their analogues in asymmetric catalysis. ![]() ![]() (3,4) Nonracemic sulfinyl compounds are also used in catalytic stereoselective reactions, both as ligands for transition metals and as chiral organocatalysts. (2) Recent reviews show the utility of various sulfur derivatives in organic synthesis. As an example, tert-butane sulfinamide introduced by Ellman and co-workers finds numerous applications in the synthesis of enantiomerically pure amines and their derivatives, in many cases exhibiting significant biological activity. ![]() It is relatively easy to introduce and remove, configurationally stable, and capable of high asymmetric induction. The sulfinyl group is considered as a valuable chiral auxiliary, used in the stereoselective preparation of variety of useful chiral compounds. These derivatives deserve attention due to their importance in modern synthetic, medicinal, and agricultural chemistry.
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